72 Two non-small-cell lung cancer cell lines, 5M2 and LC-103H, stably transfected with pSUPER-CyPA RNAi were grown as xenografts in severe combined immunodeficient (SCID) mice, and CyPA knockdown cells yielded slower-growing tumors than the cells transfected with scrambled RNAi. The gene discussed is PPIA; the disease is non-small cell lung carcinoma.