For example, treatment with anti-cancer drugs such as 5-aza-2-deoxycytidine, celecoxib, and 5-fluorouracil, decreases CyPA expression in cancer cells.77, 78, 79 Moreover, CsA and sanglifehrin A (SfA), the two immunosuppressive drugs that bind CyPA, increase the chemotherapeutic effect of cisplatin in glioblastoma multiforme.80 The gene discussed is PPIA; the disease is cancer.