Lupeol has been reported not only to induce differentiation and inhibit the growth of melanoma and leukemia cells [16-19], but also to inhibit tumor promotion in two-stage mouse skin carcinogenesis through modulating NF-κB and PI3-kinase (PI3K)/Akt pathways [20], and to inhibit growth and induce apoptosis in both prostate [21] and pancreatic cancers [22]. This evidence concerns the gene AKT1 and neoplasm.