Specifically SLC25A4 is connected with progressive external ophthalmoplegia and familial hypertrophic cardiomyopathy, TLR-3 with susceptibility or resistance to some kinds of infections, F11 with deficiency in coagulation factor XI and CYP4V2 with Bietti crystalline corneoretinal dystrophy. This evidence concerns the gene TLR3 and progressive external ophthalmoplegia.