Specifically SLC25A4 is connected with progressive external ophthalmoplegia and familial hypertrophic cardiomyopathy, TLR-3 with susceptibility or resistance to some kinds of infections, F11 with deficiency in coagulation factor XI and CYP4V2 with Bietti crystalline corneoretinal dystrophy. The gene discussed is F11; the disease is progressive external ophthalmoplegia.