Among different subtypes of adenocarcinomas, MUC5B was detected in 25% (1 of 4 cases) of adenocarcinomas with lepidic patterns, 62.5% (10 of 16 cases) of adenocarcinoms with papillary features, 66.7% (4 of 6 cases) of true papillary adenocarcinomas, 84.6% (11 of 13 cases) of adenocarcinomas NOS, and 100% (6 of 6 cases) of mucinous adenocarcinomas. This evidence concerns the gene MUC5B and colon mucinous adenocarcinoma.