DNMT1 and systemic lupus erythematosus: The finding of increased miR-148a in female mice at 30 wks of age is significant since miR-148a was reported to be highly upregulated in both human and murine lupus T cells, which contributed to DNA hypomethylation and induction of autoimmune-associated genes by targeting DNA methyltransferase 1 (DNMT1) [36].