A protective role for chaperones in neuropathies is supported by studies where exogenous induction of the heat-shock response either by diet restriction or pharmacologic modulation prevents the aggregation of PMP22 while promoting the myelination capacity of the Schwann cells (Rangaraju et al., 2008, 2009; Madorsky et al., 2009). Here, PMP22 is linked to neuropathy.