Thrombospondin 2 mediates cell-to-cell and cell-to-matrix interactions and may function as either a potent inhibitor [53, 54] or stimulator [55, 56] of tumor growth and angiogenesis in ovarian carcinoma, although no studies evaluated thrombospondin 2 according to ovarian histological type. The gene discussed is THBS2; the disease is ovarian carcinoma.