TNF and systemic inflammatory response syndrome: Serum monitoring of TNF-α in SIRS group revealed the significant elevation on the 3rd and 5th days of ICU admission, the initial mean value was 72.44 ± 18 pg/mL, 3rd day mean value was significantly elevated to 153.8 ± 52.3 pg/mL (P = 0.025), 5th day mean value was 122.2 ± 28.1 pg/mL (P = 0.034), while 7th day mean value was 79.3 ± 14.5 (P = 0.72) (Table 3).