Despite the important role of CTGF in the pathogenesis of tissue fibrosis and its potential participation in SSc owing to the well-recognized functional interactions with TGF-β, its possible participation in the EndoMT process has not been investigated, although a very recent study showed that elevated levels of CTGF in SSc microvascular endothelial cells were capable of stimulating fibroblast activation and increased motility and invasion in in vitro studies. The gene discussed is CCN2; the disease is systemic sclerosis.