Despite the important interactions between Cav-1 and TGF-β and the numerous studies that supported the role of Cav-1 in the pathogenesis of SSc [160–164], the possibility that Cav-1 may participate in the regulation of EndoMT has not been explored in detail, although a recent study examined the contribution of Cav-1 to EndoMT employing Cav-1 knockout mice [165]. The gene discussed is TGFB1; the disease is systemic sclerosis.