Indeed, in EAE and MS the immunoglobulin superfamily (IgSF), molecules intercellular CAM-1 (ICAM-1/CD54), vascular CAM-1 (VCAM-1/CD106) and activated leucocyte CAM (ALCAM/CD166) are all upregulated by vascular endothelium [26–28]. The gene discussed is ALCAM; the disease is myeloid sarcoma.