For instance, IL-1β and IL-1R antagonist gene polymorphisms were shown to be associated with MS disease severity [99, 100], with main predisposition to develop MS in patients with high ratio of IL-1β relative to the naturally occurring IL-1R antagonist and elevated expression of caspase-1, that also it has been observed in MS lesions [101]; besides, caspase-1 and IL-1R are required for the development of EAE [102, 103]. The gene discussed is CASP1; the disease is myeloid sarcoma.