All the cases achieved remission after therapy, for example, clinical symptoms got relief (such as arthritis, edema, orrhomeningitis, Raynaud's phenomenon, and oral ulcers), blood routine, urine tests, and immunological tests improved, including reduction of protein, red blood cells, white blood cells, and casts in urine, decrease of SLEDAI score, as well as increase of white blood cells, platelet, C3, and C4. The gene discussed is C4A; the disease is arthritic joint disease.