We now demonstrate that SHH tumors with TERT mutations are mostly mutually exclusive with those harboring 10q loss (p = 0.017) Notably, the relatively favorable prognosis of TERT-mutated SHH medulloblastomas may be explained by the relative lack of high-risk biomarkers [17, 18, 24, 44]. Here, TERT is linked to medulloblastoma.