According to the initial classification of tumor types with TERT mutations at frequencies over 15 % (TERT-high) vs. below this threshold (TERT-low) [13], our report suggests distinct baseline telomerase activity of the cell of origin in each of the subgroups (Group 3 ≥ Group 4 > WNT >> SHH). The gene discussed is SHH; the disease is neoplasm.