LGALS4 and sexually transmitted disease: Specifically, TotM knockdown flies (Act5C-Gal4/UAS-TotM-IR) were susceptible to STIs, but there was no evidence of susceptibility in either of +/Act5C-Gal4 or +/UAS-TotM-IR control genotypes (genotype × treatment; p = 0.00037; figure 2a).