MYC and neuroblastoma: Fig. 1B shows the results of the effect of S(+)-ibuprofen on MYCN and MYC stability in neuroblastoma cell lines. Control untreated IMR5, CHP134 and SKNBE(2)C cells express high levels of MYCN, whereas the untreated-SY5Y and SKNAS cells express high levels of MYC. As shown in Fig. 1B, S(+)-ibuprofen at 0.5 mM [IMR5, CHP134, SY5Y] and at 1.0 mM [SKNBE(2)C and SKNAS] decreased MYCN or MYC expression, respectively in a time-dependent manner.