PTEN and posterior cortical atrophy: It might be critical for PCa cells to balance down-regulation of miR-205 expression in the microenvironment of normal prostate tissue avoiding severe up-regulation of potential tumor-suppressive miR-205 target genes like PTEN or SHIP2. In contrast, metastatic cells undergoing EMT increase their cell mobility to migrate from the original location and to home to lymph nodes or other extraprostatic tissues.