Although further detailed studies are warranted to determine the exact therapeutic window of administration for the FP receptor antagonist in treatment of TBI, the data in the literature indicate that the upregulation of the inducible COX-2 enzyme occurs within several hours [12,14-16] and that the increased levels of the prostaglandin precursor remained for several days following brain trauma [18], suggesting a potential clinical application for prospective drugs in critical care. This evidence concerns the gene PTGS2 and brain injury.