Consistent with the resultof earlier studies, knockdown of PLU1 reduced MCF7 breast cancer cellproliferation and concomitantly upregulated expression of the Breastcancer1, early onset (BRCA1), Caveolin 1(CAV1), and HOXA5 genes as a result of increasedH3K4me3 levels on their promoters [34]. Here, CAV1 is linked to breast carcinoma.