Consistent with the resultof earlier studies, knockdown of PLU1 reduced MCF7 breast cancer cellproliferation and concomitantly upregulated expression of the Breastcancer1, early onset (BRCA1), Caveolin 1(CAV1), and HOXA5 genes as a result of increasedH3K4me3 levels on their promoters [34]. The gene discussed is KDM5B; the disease is breast carcinoma.