About 20 to 30% of all newly diagnosed breast malignancies are hormone receptor-negative (HRneg), including the approximately 15% referred to as triple-negative (Tneg), because they lack tumor cell overexpression of estrogen and progesterone receptors (ER, PR) as well as the human epidermal growth factor receptor-2 (HER2)[1,2]. This evidence concerns the gene ERBB2 and neoplasm.