Taken together, these common immune system and cytokine links suggest that higher levels of B-cell mediated signaling as reflected by lower ICS values are associated with a lower risk of distant metastatic recurrence by HRneg/Tneg breast cancers, a conclusion also supported in part by a report that high B-cell/low IL-8 gene expression is associated with good prognosis Tneg breast cancers[24]. This evidence concerns the gene CXCL8 and breast carcinoma.