IFNG and cancer: The IPA knowledge base linked together only four of the five ICS genes, including CLIC5, via interconnections through cytokines IL10 and IFN-γ, as illustrated in Figure 4B. However, the apparently disconnected XCL2 gene (chemokine ligand 2), also referred to as lymphotactin-2, is a well-documented immune system cytokine known to be mechanistically involved in cancer cell migration and proliferation[32,33].