Of interest, Ionescu et al. [13] presented the case of a 45-year-old woman who had developed RA during treatment with PEG-IFN-α-2b and ribavirin, whose retreatment with PEG-IFN α-2a and ribavirin for relapsing CHC caused the reappearance of RA. This evidence concerns the gene IFNA1 and cryohydrocytosis.