BRCA2 and cancer: The vast majority of 1424 women with breast cancer included in this study were non high-risk BRCA1 or BRCA2 mutation carriers: only 243 (17.1%) patients had one of BRCA1 mutations indicated in Table 2 and none of them had any of 11 genotyped mutations in BRCA2. The number of patients with family cancer history was similar to the number of sporadic tumor cases (785 vs. 639), as shown in Table 1.