It is now well known that hypoxia causes the stabilization of HIF-1α monomer that translocates to the nucleus where it heterodimerizes with HIF-1β and HIF-1 complex binds to the hypoxia responsive element (HRE) on the promoter regions of target genes in order to promote tumor survival, invasion, and metastasis [22–25]. The gene discussed is HIF1A; the disease is neoplasm.