Whereas they observed a regulatory function of IL-18/IL-18Rα in CD8 T cell contraction, their experiments revealed that neither IL-18 nor IL-18Rα is required for the generation, contraction, or maintenance of memory CD4 and CD8 T cells in response to infection with an attenuated strain of Listeria monocytogenes [41]. The gene discussed is IL18; the disease is infection.