Zhao et al. demonstrate that TCF-1 (T cell factor 1) and LEF-1 (lymphoid enhancer-binding factor 1), the effector transcription factors of canonical Wnt pathway in a manner similar to IL-7Rα and CD62L, exhibit dynamic expression changes during expansion of antigen-specific CD8 T cells in response to Listeria monocytogenes infection [36]. The gene discussed is IL7R; the disease is listeriosis.