In ConA-induced mouse AIH models, TLRs-My88 signaling accelerates the liver damage, whereas a decrease in CpG-containing oligodeoxynucleotides (CpG-ODN) treatment attenuates ConA-induced mouse AIH. CpG-ODN is a ligand for TLR-9 and is used as an immunological adjuvant.LR-3 also has an important role in liver inflammation and jury in ConA-induced mouse AIH models.In AIH, monocytes were higher in number, displayed a higher tumor necrosis factor alpha (TNF-α), and expressed high levels of TLR-4 compared with healthy controls. The gene discussed is LRP5; the disease is autoimmune hepatitis.