Soluble liver antigen-specific IFN-γ responses were significantly more frequent in AIH patients. This response was positively correlated with transaminase levels and decreases with immune-suppressive treatment or disease in remission state.Production of IFN-γ is needed for the pathogenesis in a mouse model of fulminant liver inflammation and murine model of hepatitis. The gene discussed is IFNG; the disease is inflammatory response.