The activation of p38 MAPK signaling pathway was up-regulated in experimental AIH, and the inhibition of p38 MAPK reduced hepatic inflammation and injury.IL-17 contributes to the pathogenesis of AIH via the induction of MAPK signaling pathway.Apolipoprotein A2 (Apo A2) suppressed ConA-induced hepatitis by inhibiting the phosphorylation of ERK1/2 and cJun and reduced the intra-hepatic infiltration of inflammatory cells. Here, MAPK3 is linked to hepatitis A virus infection.