From molecular analyses, we concluded that the reverse process of myocardial fibrosis was dependent on upregulation of PPARα and PPARγ expression, downregulation of NF-κB expression, and suppressing TNF-α, ICAM-1, and MCP-1 production through the NF-κB signaling pathway. The gene discussed is NFKB1; the disease is Myocardial fibrosis.