CFTR and cystic fibrosis: Liver disease will have a growing impact on survival and quality of life of cystic fibrosis patients because a longer life expectancy and for this it is important its early recognition and a correct clinical management aimed atdelaying the onset of complications.This review could represent an opportunity to encourage researchers to better investigate genotype-phenotype correlation associated with the development of CFLD, especially for non-CFTR genetic polymorphisms, and detect predisposed individuals.