KLK3 and benign prostatic hyperplasia: Kijvikai, in a systematic review, found that prostate volume by digital rectal examination, identifying large-volume prostates, is impactful to the natural history of benign prostatic hyperplasia, whereas prostate-specific antigen would be additional tool for predicting disease progression and guiding therapeutic options, being the prostate ultrasonography reserved for guiding eventual biopsy or surgical treatment [18].