However, HPV oncoproteins reduce the IFN and MCP1 secretion by the keratinocyte; HPV18-E7 can reduce IRF-1 expression in cervical tissue from transgenic mice expressing HPV18 E6/E7 [28], while HPV18-E6 can inhibit the phosphorylation of molecules involved in IFN signaling as Tyk2 kinase, STAT1 and STAT2, in cervical cancer cell lines [29]. The gene discussed is IFNA1; the disease is cervical carcinoma.