On the other hand, the expression of HLA-DR, CD54 and CD58 in keratinocytes increases with disease severity, which together with the observed accumulation of activated leucocytes below the lesion, point to the development of a CIN-related but weak immune response since TNFα is down-regulated and IL-10 expression is increased [49]. This evidence concerns the gene ICAM1 and cervical squamous intraepithelial neoplasia.