TNF and neoplasm: In order to understand the role of various PUFAs on the growth of normal and tumor cells, we studied the effect of various PUFAs: LA, GLA, AA, ALA, EPA and DHA on the growth of RWPE-1(human prostate epithelial cell) and PC-3 (human prostatic carcinoma cell) and their effects on fatty acid metabolism and ability to modulate the production of IL-6, TNF-α, lipoxin A4 and free radical generation and the results are reported here.