In confirmation of this, it is noteworthy (see Table 1) that the epitopes incorporated into the two tetramers that gave positive labelling of malaria antigen-specific CD8+ T cells were high affinity MHC class I binders (IC50 = 12-17 nM) and peptide pools containing these peptides also stimulated strong ELISpot responses. This evidence concerns the gene CD8A and malaria.