In the present analysis, we therefore ascertained how the sensitivities of urine- and sputum-based approaches to diagnosis using the Xpert MTB/RIF and Determine TB-LAM assays varied according to disease severity as reflected by CD4 cell count, symptom intensity, C-reactive protein (CRP) concentration, hemoglobin concentration and vital status at 90 days of follow-up. This evidence concerns the gene CRP and tuberculosis.