LAT and neoplasm: Although the expression of LAT1 mRNA was increased in tumor tissue (mean ± S.D. = 1.78 ± 3.95) compared with non-tumor tissue (0.42 ± 1.36, P < 0.0001, Figure 1A), expression of LAT2 and LAT3 mRNAs was decreased in the tumors (0.14 ± 0.72 versus 0.74 ± 0.76, P < 0.0001, Figure 1B, and 0.32 ± 0.31 versus 0.69 ± 0.55, P < 0.0001, Figure 1C, respectively).