There is no data available about effect of MK-886 on TNF-α and IL-1β in global ischemia reperfusion injury by using heart transplantation model; however, in a study of other model Al-Amran et al. (2011) showed that MK-886 treatment significantly decreased serum TNF-α in hemorrhagic shock-induced acute lung injury [37]. This evidence concerns the gene IL1B and acute lung injury.