Currently 27 missense mutations in Cdc48 gene have been isolated from IBMPFD (e.g., I27V, R93C, R95C, R95G, G97E, P137L, R155C, R155S, R155L, R155P, G157R, R159H, R159C, L198W, I206F, A232E, T262A, N387H, A439S, and A439P) and/or ALS (R95H, I151V, R155H, R159G, R191G, R191Q, and D592N) patients worldwide including countries like China, Japan, Argentina, USA, Germany, Italy, and Australia [90, 105–108]. The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.