AR and posterior cortical atrophy: To determine whether the T877A mutation of the AR influences the effects of genistein on PCa cell proliferation, we applied two approaches, (a) using cell lines that naturally have WT AR (LAPC-4 cells) or T877A mutant AR (LNCaP cells) and (b) using an AR-null cell line (PC-3) transfected transiently with exogenous WT or T877A mutant AR in order to overcome any biological discrepancies from using two different cell lines.