AR and posterior cortical atrophy: The T877A AR variant is of obvious biological relevance as it has been reported in up to 12.5% of hormone-refractory PCa [40,72,73] and is considered an example of a range of AR variants in PCa that have promiscuous ligand specificity, such as the K580R and the V715M variants that are induced by estradiol at 0.1nmol/L [39,48,74].