Subsequent to our report[12], in vitro MIF inhibition experiments have been conducted using small molecules for various cancers, such as colon cancer inhibited by ISO-1 [43], prostate cancer inhibited by ISO-1 [44], lung cancer inhibited by ISO-1 [45], and 4-Iodo-6-phenylpyrimidine (4-IPP) [45], glioblastoma inhibited by ISO-1[46-48], and adenoid cystic carcinoma inhibited by ISO-1[49]. The gene discussed is MIF; the disease is colonic neoplasm.