Accordingly, using clinical and microarray data from STS patients, we conducted a simulation based on the permutation test, to extract genes that have both the functions of “a diagnostic marker to discriminate between MFH and MFS” and “a prognostic marker for the outcome of overall STS”, which yielded four statistically significant genes, including MIF and SCD1. Furthermore, we investigated the potential of the combination of MIF and SCD1 as a prognostic marker using clinical and microarray data from STS patients. This evidence concerns the gene MIF and telomere syndrome.