The results, presented in Figure 5A, showed that the binding of IE complex on ICP0 promoter was reduced in drug treated cells at 4 h post-infection, indicating that HM interfered in the recruitment of Vp16-HCF-1-Oct-1 complex on TAATGARAT region of ICP0 promoter, leading to the decreased viral transcription. This evidence concerns the gene HCFC1 and infection.