We found that 1) senescent signaling pathways are activated in airway epithelium in patients with asthma, 2) TSLP stimulation induced cellular senescence and silencing of cellular senescence pathways inhibits TSLP-induced airway remodeling in vitro and 3) Stat3-targeted therapies overcome TSLP-induced airway remodeling by inhibiting cellular senescence in vitro and in vivo. This evidence concerns the gene TSLP and asthma.