In all three strains the level of expression of IL1F6 as assessed by qPCR correlated significantly with LCN-2 and HAVCR1, two markers of proximal tubular damage (r values for NZM2410: 0.5562, p = 0.0021 and 0.8489, p<0.0001; r values for NZB/W: 0.3729, p = 0.0077 and 0.8186, p<0.0001; r values for NZW/BXSB: 0.9063, p<0.0001 and 0.9277, p<0.0001), showing that progressive nephritis is associated with damage to the entire tubular system. This evidence concerns the gene IL36A and nephritis.