Transplantation of LSECs could provide a permanent source of FVIII and a cure for hemophilia A. Successful transplantation of rodent LSECs has been described in the CD26 (dipeptidyl peptidase IV, DPPIV) knockout rat [12], [13] and in a hemophilia A mouse model [9], [14]. The gene discussed is DPP4; the disease is hemophilia A.