However, our results are in agreement to those reported by Rajpathak and coworkers who observed, in a nested case-control study conducted in the framework of the Diabetes Prevention Program, a positive association between serum sTfR levels and T2DM risk even after adjusting by ferritin levels, thus suggesting another potential mechanism linking sTfR and T2DM unrelated to iron overload [7]. The gene discussed is TFRC; the disease is Tangier disease.