However a reduction in BIM expression occurred soon after EBV infection of B cells in culture and did not initially involve detectable CpG methylation, but correlated with the deposition of the polycomb signature H3K27me3 on chromatin proximal to the transcription start site (TSS; Paschos et al., 2009,2012). The gene discussed is BCL2L11; the disease is Epstein-Barr virus infection.