We further discuss how anomalies in the expression of FMRP alter the condition of its targets and ultimately, highlight a subset of FMRP target mRNAs dysregulated in autism spectrum disorders (ASDs), mood disorders (MDs) including bipolar disorder (BD), major depressive disorder (MDD), attention deficit hyperactive disorder (ADHD), and schizophrenia (SCZ). The gene discussed is FMR1; the disease is autism spectrum disorder.