An expression analysis of hepatic genes involved in bile synthesis and secretion (Figure 4B), showed striking reductions in the transcript levels of the major transporters of bile acid and cholesterol (Abcb11, Slc10a1, Abcb1a, Abcg5 and Abcg8) and the induction of several genes involved in rescue from cholestasis. The gene discussed is ABCG5; the disease is cholestasis.