The disruption of the IS/OS may be related not only to the period of about 1 year between the onset of macular edema and the resorption of intraretinal fluid[9] after IFN therapy, but also to an apoptotic action of the IFN, with the formation of capsase-4 and -8 as already noted with other anti-VEGF agents[10]. The gene discussed is IFNA1; the disease is macular retinal edema.