CASP4 and neoplasm: This region encompasses several known tumor suppressor genes with a role in apoptosis such as SDHD and members of the cysteine-aspartic acid protease (caspase) family including CASP4 and CASP12. Whole chromosome 9 loss was found in two tumors and segmental losses in four tumors with recurrent regions at 9pter-p13.2 and 9p13.1-11.2.