For example, migrants from the Indian subcontinent who settled in the USA, UK, or other European countries have been reported to have increased obesity, apolipoprotein B levels [7, 11, 49], fasting plasma insulin [11, 49], C-reactive protein [49], serum triglyceride [50], and decreased β cell functions [11, 49] compared to the natives of those countries [11, 49–51]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.