Notably, MAP4K4 expression is upregulated by EGFRvIII expression in glioma cells [52], and it is known to interact with the FERM domain of classical ERM proteins and phosphorylates them to promote F-actin anchoring and stabilization of lamellipodia in response to EGF and PDGF [53]. This evidence concerns the gene MAP4K4 and central nervous system cancer.