IGF1 and leiomyoma: Several growth factors, such as vascular endothelial growth factor (VEGF), EGF, heparin binding epidermal growth factor (HB-EGF), PDGF, IGF, TGF-α, TGF-β, acidic fibroblast growth factor (aFGF), and basic fibroblast growth factor (bFGF), and their respective receptors have been demonstrated to play a role in leiomyoma growth [91, 92].