However, compared to each single treatment, combination treatment in PC3 tumors significantly decreased p-ATM levels (p=0.006, combination verse BEZ235; p<0.0001, combination vs. PAN) and in PC3-AR tumors (p<0.0001, combination vs. BEZ235; p=0.0001, combination vs. PAN) (Fig. 6B). This evidence concerns the gene ATM and polyarteritis nodosa.