CD274 and neoplasm: Finally, expression levels of PD-L1, the key tumor ligand targeted in the anti-checkpoint immunotherapy trials, tracks quite well with the above immune evasion signature in subgroups of not only LUSC, but also LUAD, as especially well visualized in heat maps for individual immune related pathways, which each track closely with an immune evasion signature in the LUSC and LUAD, TCGA samples (Fig. 4).